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Journal / Biology / PMS2 carente, ERCC1, Ku86, CcOI in Difetti del…
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Biology

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PMS2 carente, ERCC1, Ku86, CcOI in Difetti del campo durante la progressione a tumore del colon
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PMS2 carente, ERCC1, Ku86, CcOI in Difetti del campo durante la progressione a tumore del colon

Article DOI: 10.3791/1931-v • 28:16 min • July 28th, 2010
July 28th, 2010 •
1, 1, 1, 1, 1, 1, 2,3, 1,4, 3, 5, 5, 5, 1
1Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, 2Southern Arizona Veterans Affairs Health Care System, Tucson, AZ, 3Department of Surgery, College of Medicine, University of Arizona, Tucson, 4Biomedical Diagnostics and Research, Tucson, AZ, 5Department of Medicine, College of Medicine, University of Arizona, Tucson

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Ridotta espressione / assenza di PMS2 e / o ERCC1 nelle cripte intero è un evento frequente nel raggio di 10 cm su ogni lato degli adenocarcinomi del colon, probabilmente in base ad un difetto del campo con elevata mutevolezza e la progressione del cancro. Carenza di Ku86 o CcOI è molto meno frequente in questi difetti del campo.

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Biologia Cellulare Numero 41 di riparazione del DNA apoptosi difetti del campo cancro del colon PMS2 ERCC1 citocromo c ossidasi subunità I Ku86 Immunoistochimica resezione del cancro
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