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Journal / Biology / PMS2 deficiente, ERCC1, Ku86, CCOI Defeitos em…
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PMS2 deficiente, ERCC1, Ku86, CCOI Defeitos em campo durante a progressão para cancro do cólon
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PMS2 deficiente, ERCC1, Ku86, CCOI Defeitos em campo durante a progressão para cancro do cólon

Article DOI: 10.3791/1931-v • 28:16 min • July 28th, 2010
July 28th, 2010 •
1, 1, 1, 1, 1, 1, 2,3, 1,4, 3, 5, 5, 5, 1
1Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, 2Southern Arizona Veterans Affairs Health Care System, Tucson, AZ, 3Department of Surgery, College of Medicine, University of Arizona, Tucson, 4Biomedical Diagnostics and Research, Tucson, AZ, 5Department of Medicine, College of Medicine, University of Arizona, Tucson

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Expressão reduzida / ausente de PMS2 e / ou ERCC1 em criptas inteiro é um evento freqüente dentro de 10 centímetros em cada lado do adenocarcinomas do cólon, provavelmente a base de um defeito de campo com alta mutabilidade ea progressão para o câncer. Deficiência em Ku86 ou CCOI é muito menos freqüente nesses defeitos de campo.

Tags

Biologia Celular Edição 41 Reparo do DNA apoptose defeito no campo cancro do cólon PMS2 ERCC1 citocromo c oxidase subunidade I Ku86 Imuno-histoquímica Ressecção de Câncer
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