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Consegna batterica di RNAi per DJ
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Consegna batterica di RNAi per DJ: Transkingdom RNAi

Article DOI: 10.3791/2099-v • 07:57 min • August 18th, 2010
August 18th, 2010 •
1, 1
1Institute of Pathology, Charité Campus Mitte

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Per lo sviluppo di RNA interference (RNAi) a base di terapie, una nuova strategia è stata sviluppata, transkingdom RNAi (tkRNAi). Questa tecnologia utilizza batteri non patogeni per produrre e consegnare terapeutici a breve hairpin RNA (shRNA) all'interno delle cellule bersaglio. Qui, tkRNAi stato applicato con successo per l'inversione del classico ABCB1-mediata multiresistenza ai farmaci (MDR) delle cellule tumorali.

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Microbiologia Numero 42 Transkingdom RNAi shRNA terapia genica il cancro la resistenza ai farmaci batteri
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