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Entrega bacteriana de RNAi Effectors
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Entrega bacteriana de RNAi Effectors: Transkingdom RNAi

Article DOI: 10.3791/2099-v • 07:57 min • August 18th, 2010
August 18th, 2010 •
1, 1
1Institute of Pathology, Charité Campus Mitte

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Para o desenvolvimento de interferência de RNA (RNAi) baseado em terapias, uma nova estratégia foi desenvolvida, transkingdom RNAi (tkRNAi). Esta tecnologia utiliza bactérias não-patogênicas de produzir e entregar terapêutica curto hairpin RNA (shRNA) em células-alvo. Aqui, tkRNAi foi aplicado com sucesso para a reversão de multirresistência clássica ABCB1 mediada (MDR) de células cancerosas.

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Microbiologia Edição 42 Transkingdom RNAi shRNA terapia genética câncer resistência a múltiplas drogas bactérias
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