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 JoVE Biology

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

1

1Department of Molecular Biology and Biochemistry, Department of Microbiology and Molecular Genetics, University of California, Irvine (UCI)

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    Summary

    In this candid interview, Anthony A. James explains how mosquito genetics can be exploited to control malaria and dengue transmission. Population replacement strategy, the idea that transgenic mosquitoes can be released into the wild to control disease transmission, is introduced as well as the concept of genetic drive and the design criterion for an effective genetic drive system. The ethical considerations of releasing genetically-modified organisms into the wild are also discussed.

    Date Published: 7/04/2007, Issue 5; doi: 10.3791/231

    Cite this Article

    James, A. A. Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes. J. Vis. Exp. (5), e231, doi:10.3791/231 (2007).

    Abstract

    In this candid interview, Anthony A. James explains how mosquito genetics can be exploited to control malaria and dengue transmission. Population replacement strategy, the idea that transgenic mosquitoes can be released into the wild to control disease transmission, is introduced, as well as the concept of genetic drive and the design criterion for an effective genetic drive system. The ethical considerations of releasing genetically-modified organisms into the wild are also discussed.

    Disclosures

    The authors have nothing to disclose.

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