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Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes

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1Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University

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    Summary

    In this interview, George Dimopoulos focuses on the physiological mechanisms used by mosquitoes to combat Plasmodium falciparum and dengue virus infections. Explanation is given for how key refractory genes, those genes conferring resistance to vector pathogens, are identified in the mosquito and how this knowledge can be used to generate transgenic mosquitoes that are unable to carry the malaria parasite or dengue virus.

    Date Published: 7/04/2007, Issue 5; doi: 10.3791/233

    Cite this Article

    Dimopoulos, G. Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes. J. Vis. Exp. (5), e233, doi:10.3791/233 (2007).

    Abstract

    In this interview, George Dimopoulos focuses on the physiological mechanisms used by mosquitoes to combat Plasmodium falciparum and dengue virus infections. Explanation is given for how key refractory genes, those genes conferring resistance to vector pathogens, are identified in the mosquito and how this knowledge can be used to generate transgenic mosquitoes that are unable to carry the malaria parasite or dengue virus.

    Disclosures

    The authors have nothing to disclose.

    Comments

    2 Comments

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    Posted by: AnonymousNovember 2, 2007, 10:47 AM

    Is there any phylogenetic relationship between aedes and anopheles mosquito?
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    Posted by: AnonymousMarch 16, 2009, 11:31 AM

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