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JoVE Journal Neuroscience
Automated Sholl Analysis of Digitized Neuronal Morphology at Multiple Scales
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Automated Sholl Analysis of Digitized Neuronal Morphology at Multiple Scales

Article DOI: 10.3791/2354-v • 11:42 min • November 14th, 2010
November 14th, 2010 •
*1,2, *1,2, 1, 1, 1
1Department of Cell Biology and Neuroscience, Rutgers University, 2Graduate Program in Biomedical Engineering, Rutgers University
* These authors contributed equally

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Summary
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We have developed a computer program to analyze neuronal morphology. In combination with two existing open source analysis tools, our program performs Sholl analysis and determines the number of neurites, branch points, and neurite tips. The analyses are performed so that local changes in neurite morphology can be observed.

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Automated Sholl Analysis Digitized Neuronal Morphology Multiple Scales Neurons Function Communication Inputs Action Potentials Neurites Information Processing Dendrite Morphologies Signaling Specialized Functions Neuronal Network Alterations In Morphology Fragmentation Branching Patterns Disease States Alzheimer's Disease Schizophrenia Mental Retardation Factors Shaping Dendrite Morphologies Nervous System Function And Dysfunction Sholl Analysis Counting Neurites And Branch Tips Axons Time-consuming Analysis Variability Experimenter Bias Inconsistency Bonfire Program
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