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Journal / Neuroscience / Laterale Fluid Percussie: Model van traumatisch…
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Neuroscience

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JoVE Journal Neuroscience
Laterale Fluid Percussie
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Laterale Fluid Percussie: Model van traumatisch hersenletsel bij muizen

Article DOI: 10.3791/3063-v • 11:05 min • August 22nd, 2011
August 22nd, 2011 •
1, 1, 2,3, 1, 1
1Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 2Spinal Cord and Brain Injury Research Center, 3Department of Anatomy and Neurobiology, Department of Physical Medicine and Rehabilitation, University of Kentucky Chandler Medical Center

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Laterale vloeistof percussie (LFP), een uitgewerkt model van traumatisch hersenletsel bij muizen, is aangetoond. LFP vervult drie belangrijke criteria voor dierlijke modellen: validiteit, betrouwbaarheid en klinische relevantie. De procedure, bestaande uit chirurgische craniotomie, fixatie van de hub, gevolgd door inductie van letsels die zouden ontstaan ​​bij focale en diffuse blessures, is beschreven.

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Neurowetenschappen Lateral vloeistof percussie hippocampus traumatisch hersenletsel Morris Water Maze een muis model van ernstig letsel
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