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Journal / Immunology and Infection / Selection of Plasmodium falciparum Parasites for…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells
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Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

Article DOI: 10.3791/3122-v • 10:09 min • January 3rd, 2012
January 3rd, 2012 •
1, 1
1Centre for Immunity, Infection and Evolution, University of Edinburgh

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Summary
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An in vitro model for cerebral malaria sequestration is described1. Plasmodium falciparum infected red blood cells are selected for binding to immortalized human brain microvascular endothelial cells. The selected parasites show a distinct phenotype. The selection process can be applied using various P. falciparum strains and endothelial cell lines.

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Plasmodium Falciparum Cytoadhesion Human Brain Endothelial Cells Cerebral Malaria Microvasculature Sequestration Blood Vessel Walls HBEC-5i In Vitro Model Panning Assay High-binding Parasites Pigmented Trophozoite Stage
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