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Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's Disease

Article DOI: 10.3791/3234-v • 10:09 min • February 14th, 2012
February 14th, 2012 •
1, 1, 1
1Centre for Neurobiology of Stress, Dept Biological Sciences, University of Toronto at Scarborough

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Summary
Automatic Translation

A protocol for performing unilateral 6-OHDA lesions of the medial forebrain bundle in mice is described. This method has a low mortality rate (13.3 %) with 89% of the surviving animals showing >95% loss of striatal dopamine and 90.63±-4.02 % ipsiversive rotational bias towards the side of the lesion.

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Unilaterally-lesioned 6-OHDA Mouse Model Parkinson's Disease Basal Ganglia Circuitry Parkinsonian Symptoms Cortico-striatal Synapses Striatum Pathological Abnormalities Nigro-striatal Pathway Bacterial Artificial Chromosome (BAC) Mice Green Fluorescent Proteins Direct Pathway Indirect Pathway Synaptic Plasticity Juvenile Mice Acute Models Of Parkinsonism
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