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Modelli per MAME 4D Live-Imaging cellule di tumore
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Modelli per MAME 4D Live-Imaging cellule di tumore: Interazioni microambiente che Impact progressione maligna

Article DOI: 10.3791/3661-v • 08:27 min • February 17th, 2012
February 17th, 2012 •
1, 1, 1, 1,2, 1,2, 1,2
1Department of Pharmacology, Wayne State University, 2Barbara Ann Karmanos Cancer Institute, Wayne State University

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Abbiamo sviluppato modelli di co-coltura 3D per live-cell imaging in tempo reale delle interazioni tra cellule tumorali del seno e altre cellule nel loro microambiente che hanno un impatto progressione verso un fenotipo invasivo. Questi modelli possono servire come schermi preclinici di farmaci per colpire paracrino indotte proteolitici, percorsi chemochine / citochine e chinasi implicati nella invasività.

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Medicina Immunologia seno cancro matrice extracellulare invasione proteolisi microambiente tumorale
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