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JoVE Journal Neuroscience
Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex
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Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Article DOI: 10.3791/3802-v • 09:46 min • March 28th, 2012
March 28th, 2012 •
1, 2, 2
1Neuroinformatics DTC, University of Edinburgh, 2Centre for Integrative Physiology, University of Edinburgh

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Summary
Automatic Translation

We describe procedures for preparation and electrophysiological recording from brain slices that maintain the dorsal-ventral axis of the medial entorhinal cortex (MEC). Because neural encoding of location follows a dorsal-ventral organization within the MEC, these procedures facilitate investigation of cellular mechanisms important for navigation and memory.

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Parasagittal Slices Investigation Dorsal-ventral Organization Rodent Medial Entorhinal Cortex Computation In The Brain Neurons Synaptic Inputs Membrane Ion Channels Neuronal Function Topographically Organized Neural Circuits Position Of Individual Neurons Information Encoding Sensory And Cognitive Circuits Spatial Representations Medial Entorhinal Cortex (MEC) Grid-like Firing Fields Dorsal-ventral Axis
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