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JoVE Journal
Immunology and Infection

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Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
 

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation

Article DOI: 10.3791/4208-v 14:43 min October 1st, 2012
October 1st, 2012

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Summary

Bone marrow transplantation provides a way to change the genotype of the bone marrow derived cells. If the gene of interest is expressed in both bone marrow derived cells and non-bone marrow derived cells, bone marrow transplantation can change the bone marrow derived cells to a different genotype without changing the non-bone marrow derived cell genotype.

Tags

Gene Expression Immune Cells Non-immune Cells Mouse Colitis Bone Marrow Transplantation Gene-of-interest Knockout Mice Genotype Irradiation Donor Bone Marrow Recipient Mice Wild-type Mice CD Molecules (CD45.1 And CD45.2)
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