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In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
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In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

Article DOI: 10.3791/50296-v • 07:16 min • October 20th, 2013
October 20th, 2013 •
1,2, 2,3, 1, 2,3
1Department of Radiology, University Hospital of Strasbourg, 2EA 3432, University of Strasbourg, 3Department of Bacteriology, University Hospital of Strasbourg

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Summary
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We demonstrate how to perform macrophage MR imaging using ultrasmall superparamagnetic contrast agent (USPIO) in septic arthritis, allowing an initial and longitudinal in vivo non-invasive evaluation of macrophages infiltration and an assessment of therapy efficacy.

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In Vivo Macrophage Imaging MR Targeted Contrast Agent Longitudinal Evaluation Septic Arthritis Inflammatory Response Bacterial Infection Acute Synovitis Therapy Monitoring Noninvasive Detection Magnetic Resonance Imaging Iron Nanoparticles Ultrasmall Superparamagnetic Iron Oxide (USPIO) Phagocytized Activated Macrophages Signal Changes Tissue Infiltration Quantitative Evaluation Dark Pixels Gradient Echo MR Images Particles Injection Iron Content USPIO-loaded Cells
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