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JoVE Journal Bioengineering
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Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization

Article DOI: 10.3791/51009-v • 12:13 min • October 28th, 2013
October 28th, 2013 •
1, 1, 1
1Department of Biomedical Engineering, Eindhoven University of Technology

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This model system starts from a myofibroblast-populated fibrin gel that can be used to study endogenous collagen (re)organization real-time in a nondestructive manner. The model system is very tunable, as it can be used with different cell sources, medium additives, and can be adapted easily to specific needs.

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Engineering Fibrin-based Tissue Constructs Myofibroblasts Constraints Strain Cell Reorganization Collagen Reorganization Collagen Content Collagen Organization Developing Collagenous Tissues Tissue Strains Tissue Constraint Tissue Engineers Predefined Collagen Architectures Collagen Remodeling Tissue Mechanical Loading Conditions In Vitro Model System Biaxially-constrained Myofibroblast-seeded Fibrin Constructs Uniaxial Static Loading Conditions Cyclic Uniaxial Loading Flexcell FX4000T Loading Device Time-lapse Confocal Imaging Cell Organization Collagen Structures Cell Source Healthy Cells Diseased Cells
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