Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Medicine / Modeling Spontaneous Metastatic Renal Cell…
JoVE Journal
Medicine

A subscription to JoVE is required to view this content.

JoVE Journal Medicine
Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
Journal (Medicine)
Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse
Journal (Medicine)
A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse
 

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Article DOI: 10.3791/51485-v • 12:11 min • April 29th, 2014
April 29th, 2014 •
1, 1, 2, 1, 1
1Genitourinary Section, Department of Medicine, Roswell Park Cancer Institute, 2Biological Sciences Platform, Sunnybrook Research Institute

Chapters

Summary
Automatic Translation

Models of spontaneous metastatic renal cell carcinoma (RCC) disease progression can be used for evaluating treatments in a clinically relevant setting. This protocol demonstrates different procedures for orthotopic kidney tumor cell implantation, proper nephrectomy, and finally outlines a necropsy guide for visual and bioluminescent scoring of metastatic burden and localization.

Tags

Metastatic Renal Cell Carcinoma MRCC Mice Model Nephrectomy Experimental Therapeutics Tumor Implantation Models Spontaneous Metastatic Disease Orthotopic Tumor Cell Implantation Syngeneic Model Matrigel Tumor-bearing Kidney Excision Surgical Mouse Care Micro-metastatic Disease Progression Macro-metastatic Disease Progression Bioluminescent Imaging Necropsy Guide Systemic Disease Distribution Therapeutic Testing
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter