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JoVE Journal Bioengineering
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
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Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Article DOI: 10.3791/52075-v • 08:31 min • January 15th, 2015
January 15th, 2015 •
*1,2, *1,3, 1, 1,4, 1, 2, 1,5, 1,6
1Department of Nanomedicine, Houston Methodist Research Institute, 2MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, 3Pediatrics Department of Union Hospital, Huazhong University of Science and Technology, 4CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience & Technology of China, 5Department of Medicine, Weill Cornell Medical College, 6Department of Cell and Developmental Biology, Weill Cornell Medical College
* These authors contributed equally

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Summary
Automatic Translation

Delivery remains the main challenge for the therapeutic implementation of small interfering RNA (siRNA). This protocol involves the use of a multifunctional and biocompatible siRNA delivery platform, consisting of arginine and polyethylenimine grafted porous silicon microparticles.

Tags

SiRNA Therapeutics Gene Expression Suppression SiRNA Delivery Enzymatic Degradation Intracellular Uptake Lysosomal Entrapment Biocompatible Delivery System Polyethylenimine Arginine-grafted Porous Silicon Microparticles SiRNA Loading Cytotoxicity Transfection Efficacy
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