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Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
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Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics

Article DOI: 10.3791/52157-v • 08:29 min • October 2nd, 2014
October 2nd, 2014 •
*1, *2, 3, 4, 5, 5, 2, 6
1Department of Pathology, Memorial Sloan Kettering Cancer Center, 2Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 3Department of Radiology, Weill Cornell Medical College, 4Department of Medicine, Memorial Sloan Kettering Cancer Center, 5Department of Oncology, Memorial Sloan Kettering Cancer Center, 6Department of Surgery, Memorial Sloan Kettering Cancer Center
* These authors contributed equally

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Summary
Automatic Translation

Established cancer cell lines and xenografts have been the mainstay of cancer research for the past several decades. However, recent evidence suggests that therapeutic response is greatly influenced by the tumor cell microenvironment. Therefore, we have developed an ex vivo analysis of primary tumor specimens for drug development purposes.

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Ex Vivo Treatment Response Primary Tumors Associated Metastases Preclinical Development Clinical Development Therapeutics Molecular Analysis Cancer Cell Lines Cell Culture Therapeutic Sensitivity Resistance Tumor Cell Microenvironment Traditional Culturing Methods Tumor Xenografts Drug Delivery/efficacy Tumor Cell/microenvironment Crosstalk Soluble Factors Ex Vivo Technique Fresh Tissue Sectioning Treatment Response Assessment Drug Efficacy
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