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Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses
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Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses

Article DOI: 10.3791/52232-v • 06:13 min • November 24th, 2014
November 24th, 2014 •
1, 1, 1
1Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University

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Summary
Automatic Translation

Cotton rats are extremely excitable and have a strong flight-or-fight response. A handling method optimized to reduce the stress of the animals is described which will make cotton rats more accessible as a preclinical model.

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Cotton Rat Pre-clinical Evaluation Oncolytic Viruses Anticancer Therapy Host Immune System Immunocompetent Model Antitumor Therapies Tolerized Animal Models Respiratory Viruses Syngeneic Models Mammary Carcinoma Osteosarcoma Handling Procedure Excitable Rodents Animal Stress Experimentation Calm Handling Capture Approach Timely Fashion Cotton Rat Mammary Tumor Cells Subcutaneous Tumor Formation Intratumoral Injections Intraperitoneal Injections
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