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Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch
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Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch

Article DOI: 10.3791/52403-v • 07:05 min • February 10th, 2015
February 10th, 2015 •
1, 1, 1, 1
1Department of Biomedical Engineering, University of Texas at Austin

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Summary
Automatic Translation

We describe a surgical technique that produces wire injury in the femoral artery of mice to induce neointimal hyperplasia to serve as a model testing system for the perivascular delivery of therapeutic compounds for the inhibition of restenosis.

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Murine Model Femoral Artery Wire Injury Perivascular Drug Delivery Patch Balloon Angioplasty Stenting Occlusive Vascular Disease Restenosis Bare Metal Stents Drug Eluting Stents Intimal Hyperplasia Vascular Smooth Muscle Cells Arterial Stretch Inflammation Genetically Modified Mice Surgical Technique Endothelial Denudation Neointimal Hyperplasia Arteriotomy Vascular Access Localized Cautery
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