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The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies
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The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies

Article DOI: 10.3791/52521-v • 09:29 min • February 12th, 2015
February 12th, 2015 •
1, 1
1Department of Radiology, Memorial Sloan Kettering Cancer Center

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Due to its multi-day radioactive half-life and favorable decay properties, the positron-emitting radiometal 89Zr is extremely well-suited for use in antibody-based radiopharmaceuticals for PET imaging. In this protocol, the bioconjugation, radiosynthesis, and preclinical application of 89Zr-labeled antibodies will be described.

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Bioconjugation Radiosynthesis 89Zr-DFO-labeled Antibodies Tumor-targeted PET Radiopharmaceuticals Positron-emitting Radionuclides 124I 86Y 64Cu 89Zr Antibody-based PET Imaging Agents Immunoconjugates Siderophore-derived Chelator Desferrioxamine (DFO) Prostate-specific Membrane Antigen J591 Antibody In Vivo PET Imaging Murine Model
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