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A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
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A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Article DOI: 10.3791/52562-v • 06:15 min • June 14th, 2015
June 14th, 2015 •
1, 1, 1, 1, 1, 1
1Department of Bioengineering, University of Illinois at Urbana-Champaign

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Summary
Automatic Translation

This protocol aims to alleviate the limitation of poor cell engraftment for stem cell treatment of myocardial infarctions through the use of a hydrogel system and a fibrin-based glue. With this approach, cell-to-tissue contact post-infarction can be maintained, increasing the therapeutic potential of beneficial agents at the site of injury.

Tags

Hydrogel Construct Fibrin-based Glue Therapeutics Delivery Murine Myocardial Infarction Model Cardiovascular Disease Efficacy Of Treatments Pectoral Muscle Layers Thoracotomy Ribcage Integrity Stem Cell Therapies Pro-angiogenic Benefits Anti-apoptotic Benefits Cell Delivery Approaches Engraftment Diffusion Cell-encapsulated Hydrogel Patch
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