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Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Article DOI: 10.3791/52599-v • 08:34 min • April 13th, 2015
April 13th, 2015 •
1, 2, 1, 3, 4, 4, 1
1Department of Cancer Biology, UT MD Anderson Cancer Center, 2Novartis Institutes for Biomedical Research, 3Sanofi US, 4Institute of Applied Cancer Science, UT MD Anderson Cancer Center

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Summary
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Telomere and telomerase play essential roles in ageing and tumorigenesis. The goal of this protocol is to show how to generate two murine inducible telomerase knock-in alleles and how to utilize them in the studies of tissue degeneration/regeneration and cancer.

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Murine Inducible Telomerase Alleles Tissue Degeneration Tissue Regeneration Cancer Telomere Dysfunction Telomerase Activity Ageing DNA Damage Signaling Checkpoint Responses Protocol Knock-in Alleles 4-Hydroxytamoxifen (4-OHT)-inducible TERT-Estrogen Receptor (mTERT-ER) Lox-Stopper-LoxTERT (LSL-mTERT) Telomere Dysfunction Induction Telomerase Reactivation MTERT-ER Mice LSL-mTERT Mice In Vivo Procedures Tissue Degenerative Phenotypes Tumorigenesis Impact Prostate Tumor Model G4 PB-Cre4 PtenL/L P53L/L LSL-mTERTL/L Thymic T-cell Lymphoma Model G4 Atm-/- MTERTER/ER Neural Stem Cells (NSCs) Isolation Procedures
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