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Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Article DOI: 10.3791/52641-v • 06:24 min • April 18th, 2015
April 18th, 2015 •
1, 1, 1, 1, 2, 3
1Radiology, University of Alabama at Birmingham, 2Comprehensive Cancer Center, University of Alabama at Birmingham, 3Radiation Oncology, University of Alabama at Birmingham

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Summary
Automatic Translation

The goal of this protocol is to apply dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for orthotopic pancreatic tumor xenografts in mice. DCE-MRI is a non-invasive method to analyze microvasculature in a target tissue, and useful to assess vascular response in a tumor following a novel therapy.

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Dynamic Contrast Enhanced Magnetic Resonance Imaging DCE-MRI Orthotopic Pancreatic Cancer Mouse Model Tumor Xenografts Respiratory Motion Artifact Primary Tumor Microenvironment Blood Supply Neovascularization Tumor Cell Invasion DCE-MRI Protocol Orthogonally Bent Plastic Board Motion Transfer Abdominal Area Respiratory Difficulty Orthotopic Pancreatic Tumor Modeling Small Animals Pharmacokinetic Parameters Gastrointestinal Cancer Mouse Models
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