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Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
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Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Article DOI: 10.3791/52675-v • 09:48 min • May 4th, 2015
May 4th, 2015 •
1, 1, 1, 1, 1, 2, 1
1Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 2Department of Neurological Surgery, Washington University School of Medicine

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Summary
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This protocol describes repetitive hypoxic preconditioning, or brief exposures to systemic hypoxia that reduce infarct volumes and blood-brain barrier disruption following transient middle cerebral artery occlusion in mice. It also details dual quantification of infarct volume and blood-brain barrier disruption after stroke to assess the efficacy of neurovascular protection.

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Quantification Neurovascular Protection Repetitive Hypoxic Preconditioning Transient Middle Cerebral Artery Occlusion Mice Experimental Animal Models Stroke Pathology Treatment Strategies RHP CNS Injury Focal Ischemic Stroke Infarct Volumes Blood-brain Barrier Disruption Post-stroke Inflammatory Response Endogenous CNS-protective Phenotype Dual Quantification Infarct Volume BBB Disruption Neurovascular Protection Swiss Webster Mice TMCAo (transient Middle Cerebral Artery Occlusion) Evans Blue (EB) Isoflurane Overdose
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