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JoVE Journal Behavior
Morris Water Maze Test
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Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

Article DOI: 10.3791/52706-v • 10:24 min • June 22nd, 2015
June 22nd, 2015 •
1, 2, 3, 3,4,5, 1,6
1Department of Psychology, Behavioral Neuroscience, West Virginia University, 2Department of Physiology and Pharmacology, West Virginia University, 3Department of Neurology, N. Bud Grossman Center for Memory Research and Care, University of Minnesota, 4Department of Neuroscience, N. Bud Grossman Center for Memory Research and Care, University of Minnesota, 5GRECC, VA Medical Center, 6Center for Neuroscience, Center for Basic and Translational Stroke Research, West Virginia University

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Summary
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This manuscript describes a Morris water maze (MWM) protocol tailored for use with a commonly used mouse model of Alzheimer's disease. The MWM is widely used in transgenic mouse models. Implementation of a procedure sensitive to the background strain of the mouse model is essential for detecting group differences.

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Morris Water Maze Optimization Mouse Strain Testing Environment Hippocampal-dependent Spatial Learning Transgenic Mouse Models Neurocognitive Disorders Alzheimer's Disease Behavioral Phenotype Training Procedure Probe Trials F1 FVB/N X 129S6 Background Mutant P301L Tau Memory Deficits
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