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Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
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Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Article DOI: 10.3791/53559-v • 07:07 min • February 21st, 2016
February 21st, 2016 •
1
1Cell and Matrix Biology, Institute of Zoology, Johannes Gutenberg-Universität Mainz

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Primary cilia influence various signaling pathways. The mammalian cochlea is ideal for examining planar cell polarity (PCP) signaling. Cilia dysfunction affects cochlear outgrowth, cellular patterning and hair cell orientation, readouts of PCP. Our goal is to analyze PCP signaling in mouse cochlea via phenotypic analysis, immunohistochemistry and scanning electron microscopy.

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Planar-cell-polarity Phenotypes Ciliopathy Mouse Mutant Cochlea Dissected Cochlear Epithelia Phenotypic Analysis Reagents Tissue Developmental Stage Scalpel Blade Small Pair Of Scissors Dissecting Forceps Bony Labyrinths Tectorial Membrane Black Silicone Ela
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