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Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function

Article DOI: 10.3791/53758-v • 11:47 min • January 22nd, 2017
January 22nd, 2017 •
1, 1, 1, 2, 1, 1, 1, 2, 3, 1
1Neuroscience Program, Skidmore College, 2Chemistry Department, Skidmore College, 3Health and Exercise Science Department, Skidmore College

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Summary
Automatic Translation

We present a biochemical and behavioral protocol to evaluate the efficacy of mitochondria-targeted water-soluble compounds for the treatment of Spinocerebellar ataxia type 1 (SCA1) and other cerebellar neurodegenerative diseases.

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Mitochondrial Function SCA1 Mice Water-soluble Compounds Therapeutic Effects Cerebellar Behavior Tissue Spinal Cerebellar Ataxia Type One Mitochondrial Activators Disease Pathology Water Soluble Compound Succinic Acid FDA Approved Neurodegenerative Diseases Oxidative Phosphorylation Complexes Alzheimer's Disease Huntington's Disease Behavioral Paradigms Visual Demonstration Method Section
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