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Developmental Biology

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JoVE Journal Developmental Biology
Adenoviral Gene Therapy for Diabetic Keratopathy
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Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Article DOI: 10.3791/54058-v • 11:13 min • April 7th, 2016
April 7th, 2016 •
1, 1,2, 1,2
1Eye Program, Board of Governors Regenerative Medicine Institute, Departments of Biomedical Sciences and Neurosurgery, Cedars-Sinai Medical Center, 2David Geffen School of Medicine, University of California, Los Angeles

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Summary
Automatic Translation

An example of adenoviral gene therapy in the human diabetic organ-cultured corneas is presented towards the normalization of delayed wound healing and markedly reduced epithelial stem cell marker expression in these corneas. It also describes the optimization of this process in stem cell-enriched limbal epithelial cultures.

Tags

Adenoviral Gene Therapy Diabetic Keratopathy Wound Healing Stem Cell Marker Expression Human Organ-cultured Corneas Limbal Epithelial Cells Molecular Alterations Diabetic Corneas Adenoviral Gene Therapy Organ-cultured Corneas Diabetic Epithelial Wound Healing Abnormal Expression SEM Molecules Gene Therapy Approaches Corneal Epithelial Wound Healing Stem Cell Function Corneal Diseases Stem Cell Dysfunction Ultradiabetic Corneal Stem Cells Agar-collagen Mixture Air-liquid Interface Culture
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