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Characterizing Multiscale Mechanical Properties of Brain Tissue Using Atomic Force Microscopy, Impact Indentation, and Rheometry
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Characterizing Multiscale Mechanical Properties of Brain Tissue Using Atomic Force Microscopy, Impact Indentation, and Rheometry

Article DOI: 10.3791/54201-v • 11:19 min • September 6th, 2016
September 6th, 2016 •
1, 2, 3, 2, 2, 4, 4, 4, 1,2
1Department of Materials Science and Engineering, Massachusetts Institute of Technology, 2Department of Biological Engineering, Massachusetts Institute of Technology, 3Department of Mechanical Engineering, Massachusetts Institute of Technology, 4Department of Neurology, The F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School

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Summary
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We present a set of techniques to characterize the viscoelastic mechanical properties of brain at the micro-, meso-, and macro-scales.

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Multiscale Mechanical Properties Brain Tissue Atomic Force Microscopy Impact Indentation Rheometry Viscoelastic Properties Biological Engineering High Rates Of Loading Multiple Sclerosis Autism Low Stiffness High Hydration Loading Conditions Material Volumes Single Cell Entire Brain Brain Injury Modeling Protective Strategies Compliant Biological Tissues Heart Liver Contact Establishment AFM Probe
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