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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Article DOI: 10.3791/54422-v • 10:53 min • October 10th, 2016
October 10th, 2016 •
1, 1, 1
1Leslie Dan Faculty of Pharmacy, University of Toronto

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Summary
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The key steps of living anionic polymerization of phenyl glycidyl ether (PheGE) on methoxy-polyethylene glycol (mPEG-b-PPheGE) are described. The resulting block copolymer micelles (BCMs) were loaded with doxorubicin 14% (wt%) and sustained release of drug over 4 days under physiologically relevant conditions was obtained.

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Anionic Polymerization Amphiphilic Copolymer Block Copolymer Micelles β-β Stacking Interactions Hydrophobic Drug Formulation Synthesis Of Block Copolymer Ring-opening Anionic Polymerization Polymeric Drug Delivery Methoxypolyethylene Glycol Molecular Weight 5000 Dried Flask Stirring Bar Flushing Adapter Septum Argon Manifold Vacuum Position
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