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The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
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The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)

Article DOI: 10.3791/54504-v • 06:49 min • November 20th, 2016
November 20th, 2016 •
1, 1, 1,2
1Department of Ophthalmology and Visual Sciences, University of Maryland-Baltimore School of Medicine, 2Anatomy and Neurobiology, University of Maryland-Baltimore School of Medicine

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Summary
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The following report describes how to replicate the rodent model of nonarteritic anterior ischemic optic neuropathy (rNAION), using the appropriate dye, contact lens and laser parameters. We also reveal the appropriate steps for evaluating the rNAION lesion in vivo.

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Rodent Model Nonarteritic Anterior Ischemic Optic Neuropathy Stroke Response Mechanisms Neuroprotective Agents Optic Nerve Stroke Edema Mechanisms Post-stroke Inflammation Protection And Repair Pathways Isolated Anterior Optic Nerve Damage Painless Technique Reproducible Damage Variation Nerve Damage Models Exo-ischemia Effects Analysis Custom-made Contact Lens Rose Bengal Solution PH 7.4 Phosphate Buffered Saline Sterilization Process Neodymium Yttrium Aluminum Garnet Ophthalmic Medical Laser
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