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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis

Article DOI: 10.3791/54649-v • 06:09 min • July 18th, 2017
July 18th, 2017 •
1, 1, 3, 1,3, 1, 1, 3, 1,2,4
1Department of Radiology, Case Western Reserve University, 2Department of Pediatrics, Case Western Reserve University, 3Department of Urology, Case Western Reserve University, 4Department of Biomedical Engineering, Case Western Reserve University

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This manuscript describes a rat surgical model of pyelonephritis using direct intra-renal infection by Escherichia coli into the renal pelvis. The experimental procedure can be utilized to study the pathogenesis of pyelonephritis as well as the associated inflammation and fibrosis.

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Intrarenal Injection Escherichia Coli Rat Model Pyelonephritis Surgical Method Antibiotic Therapy Recurrent Infections Residual Infections Renal Reflux Bacterial Injection Bolus Anesthetizing The Rat Surgical Platform Decubitus Position Skin Preparation Disinfectant Retroperitoneal Incision Subcutaneous Tissue Abdominal Cavity Liver Visualization
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