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JoVE Journal
Biochemistry

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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
 

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Article DOI: 10.3791/54722-v 09:57 min December 23rd, 2016
December 23rd, 2016

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Summary

To deliver cancer drugs to tumor sites with high specificity and reduced side effects, new methods based on nanoparticles are required. Here, we describe disulfide cross-linked micelles that can be easily prepared by hydrogen peroxide-mediated oxidation and are able to dissociate efficiently under a reducing tumor environment to release payloads.

Tags

Micelles Drug Delivery Nano-medicine Disulfide Cross-linking Polyethylene Glycol DMF Hydroxy Benzotriazole DIC Lysine Reaction Completion Ether Precipitation
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