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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Article DOI: 10.3791/54751-v • 11:43 min • December 30th, 2016
December 30th, 2016 •
*1,2,3, *1, 1, 1,2, 1, 3,4, 1,5,6, 1, 2, 3, 3, 1
1Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, 2Department of Chemistry, Technische Universität München, 3GE Global Research, 4Zentralinstitut für Medizintechnik der Technischen Universität München (IMETUM), Technische Universität München, 5Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, 6IDG Institute of Developmental Genetics, Helmholtz Zentrum München
* These authors contributed equally

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Summary
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Dynamic nuclear polarization with subsequent sample dissolution has enabled real-time studies of metabolism in biological systems. Hyperpolarized [1-13C]pyruvate was used to study lactate dehydrogenase activity in a prostate carcinoma cell line in vitro.

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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy Imaging Dynamic Nuclear Polarization Carbon 13 Magnetic Resonance Retroscopic Imaging Resonant Signal Localized VR Techniques View Of Metabolism Naturally Occurring Substances Real Time Cancer Metabolism In Vitro Animal Models Human Patients Tumor Localization Metabolic Tumor Sub-types Monitoring Treatment Gadoterate Meglumine One-carbon 13 Pyruvate Trityl Radical OX063 DNP Polarizer Software
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