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JoVE Journal
Cancer Research

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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
 

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Article DOI: 10.3791/54893-v 08:55 min November 30th, 2016
November 30th, 2016

Chapters

Summary

Mice bearing the Colon-26 (C26) carcinoma represent a classical model of cancer cachexia. Progressive muscle wasting occurs in association with tumor growth, over-expression of muscle-specific ubiquitin ligases, and reductions in muscle cross-sectional area. Fat loss is also observed. Cachexia is studied in a time-dependent manner with increasing severity of wasting.

Tags

Colon-26 Carcinoma Tumor-bearing Mouse Cancer Cachexia Muscle Wasting Muscle Weakness Muscle Catabolism Hyperinflammatory Cytokine Levels Cachectic Phenotype Implantation Of C26 Tumors CD2F1 Mice Body Weight Loss Blood Collection
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