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Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
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Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Article DOI: 10.3791/55658-v • 11:42 min • July 10th, 2017
July 10th, 2017 •
*1, *2, 1, 1, 1, 1
1Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 2Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University
* These authors contributed equally

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Summary
Automatic Translation

This work describes a fluorescence microscopy-based method for the study of platelet adhesion, spreading, and secretion under flow. This versatile platform enables the investigation of platelet function for mechanistic research on thrombosis and hemostasis.

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Live-cell Imaging Platelet Degranulation Platelet Secretion Flow Subcellular Level Platelet Biology Mast Cells Platelet Isolation Preactivation End Point Stages Real-time Images Release Kinetics Platelet Granular Release Silvia Pignatelli Arjan Barendrecht Degrease Cover Glasses Chromosulfuric Acid Distilled Water Paraffin Film
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