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JoVE Journal
Bioengineering

This content is Open Access.

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
 

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Article DOI: 10.3791/56334-v 10:51 min September 26th, 2017
September 26th, 2017

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Summary

This publication describes the fabrication of an organ-on-chip device with integrated electrodes for direct quantification of transendothelial electrical resistance (TEER). For validation, the blood-brain barrier was mimicked inside this microfluidic device and its barrier function was monitored. The presented methods for electrode integration and direct TEER quantification are generally applicable.

Tags

Fabrication Validation Organ-on-chip System Integrated Electrodes Transendothelial Electrical Resistance TEER Measurements Blood-brain Barrier Micro-fluidic Chip Barrier Function Organs-on-Chips Personalized Medicine Drug Discovery Lung-on-Chip Gut-on-Chip PDMS Base Agent Curing Agent
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