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Neuroscience

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JoVE Journal Neuroscience
Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain
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Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Article DOI: 10.3791/57391-v • 08:23 min • May 12th, 2018
May 12th, 2018 •
*1, *1, *1, *1,2, *1,2, *1,3, 1, 4, 4, 4, 1,3
1Department of Anesthesiology, Ohio State University College of Medicine, 2Medical Student Research Program, Ohio State University College of Medicine, 3Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, 4Department of Neuroscience, University of Kentucky Medical Center
* These authors contributed equally

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Summary
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This study explores the novel use of enzyme-based microelectrode array (MEA) technology to monitor in vivo neurotransmitter activity in piglets. The hypothesis was that glutamate dysregulation contributes to the mechanism of anesthetic neurotoxicity. Here, we present a protocol to adapt MEA technology to study the mechanism of anesthesia-induced neurotoxicity.

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Microelectrode Array Technology Anesthesia-induced Neurotoxicity Neurotransmitters Glutamate Activity In Vivo Measurement Spatial Resolution Temporal Resolution Clinically-relevant Animal Model Pediatric Brain Trauma Epilepsy Stroke Piglet Model Implementation Microelectrode Arrays Specialized Skill Set Surgical Procedure Microelectrode Placement Brain Growth Time Acclimation Period Trained Staff
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