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JoVE Journal Bioengineering
Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
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Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Article DOI: 10.3791/58219-v • 09:04 min • September 10th, 2018
September 10th, 2018 •
1, 1,2, 1,3, 1, 4, 1
1Laboratory for Reproductive Health, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 2College of Veterinary Medicine, Hunan Agricultural University, 3Key Laboratory of Chemical Engineering Process and Technology for High-efficiency Conversion, College of Chemistry and Material Sciences, Heilongjiang University, 4Department of Obstetrics and Gynecology, Wayne State University School of Medicine

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Summary
Automatic Translation

We describe a system that utilizes three methods to evaluate the safety and effectiveness of placenta-targeted drug delivery: in vivo imaging to monitor nanoparticle accumulation, high-frequency ultrasound to monitor placental and fetal development, and HPLC to quantify drug delivery to tissue.

Tags

Placenta-targeted Drug Delivery Effectiveness Safety Nanomedicine Drug-loaded Nanoparticles Biochemical Measurement Placenta-mediated Pregnancy Complications Visual Demonstration High-frequency Ultrasound Evaluation Embryonic Development Intravenous Nanoparticle Injection In Vivo Fluorescence Imaging
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