The Journal of Visualized Experiments (JoVE) is a peer reviewed, PubMed-indexed video journal. Our mission is to increase the productivity of scientific research.

Recommend to Librarian

Automatic Translation

This translation into Chinese was automatically generated through Google Translate.
English Version | Other Languages

 JoVE General

专访:糖脂抗原提呈CD1d及NKT细胞活化治疗潜力

Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology

You must be subscribed to JoVE to access this content.

This article is a part of   JoVE General. If you think this article would be useful for your research, please recommend JoVE to your institution's librarian.

Recommend JoVE to Your Librarian

Current Access Through Your IP Address

You do not have access to any JoVE content through your current IP address.

IP: 54.234.126.92, User IP: 54.234.126.92, User IP Hex: 921337436

Current Access Through Your Registered Email Address

You aren't signed into JoVE. If your institution subscribes to JoVE, please or create an account with your institutional email address to access this content.

 

Video Article Chapters

Cite this Article: 专访:糖脂抗原提呈CD1d及NKT细胞活化治疗潜力

Kronenberg, M. Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation. J. Vis. Exp. (10), e635, doi:10.3791/635 (2007).

Abstract: 专访:糖脂抗原提呈CD1d及NKT细胞活化治疗潜力

自然杀伤T细胞(NKT细胞)的免疫反应的癌症,调节autioimmune疾病,传染性病原体的间隙,artheriosclerotic斑块的发展的关键因素。在这次采访中,米奇Kronenberg讨论他的实验室的努力去了解通过糖脂抗原激活NKT细胞的机制。这些研究的核心是CD1d - 呈现糖脂NKT细胞的抗原提呈分子。 CD1d四聚体技术的问世,由Kronenberg实验室开发出一种技术,具体糖脂反应性T细胞亚群的分类和识别的关键。米奇解释糖脂受体激动剂作为治疗药物激活NKT细胞在癌症患者中,以及如何CD1d四聚体可以用来评估在体内糖脂受体激动剂治疗后NKT细胞人口的状态。正在进行的临床试验,使用这些受体激动剂的现状进行了讨论,以及米奇的预测,在免疫学领域的地区,将出现在不久的将来的重要性。

Disclosures: 专访:糖脂抗原提呈CD1d及NKT细胞活化治疗潜力

References: 专访:糖脂抗原提呈CD1d及NKT细胞活化治疗潜力

1. Khurana A and Kronenberg M. "A Method for Production of Recombinant CD1d Protein in Insect Cells" (12/10/2007) Journal of Visualized Experiments

Ask the Author: 专访:糖脂抗原提呈CD1d及NKT细胞活化治疗潜力

2 Comments

i cann't see more detail in this Vedeo. Who can answer the proplem for me?

1

Reply

Posted by: siriwan W.February 28, 2012, 9:15 AM

I am looking for information regarding to CD1d presenting glycolipids. And I hope this video can provide a vivid presentation of the mechanism as I have limited background knowledge about this topic.

2

Reply

Posted by: Shuyi Y.July 16, 2012, 9:59 PM

Post a Question / Comment / Request

You must be signed in to post a comment. Please or create an account.

Waiting
simple hit counter