Andrés A. Trabanco Discovery Chemistry Janssen Research and Development Biography Publications Institution JoVE Articles Andrés A. Trabanco has not added a biography. If you are Andrés A. Trabanco and would like to personalize this page please email our Author Liaison for assistance. Publications Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery Journal of the American Chemical Society. May, 2020 | Pubmed ID: 32379965 Hydrosulfonylation of Alkenes with Sulfonyl Chlorides Under Visible Light Activation Angewandte Chemie (International Ed. in English). Jul, 2020 | Pubmed ID: 32286720 Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes Journal of the American Chemical Society. 01, 2020 | Pubmed ID: 31881153 MGluR2 Positive Allosteric Modulators: an Updated Patent Review (2013-2018) Expert Opinion on Therapeutic Patents. 07, 2019 | Pubmed ID: 31242055 Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid Angewandte Chemie (International Ed. in English). 06, 2019 | Pubmed ID: 31020767 Progress Toward Allosteric Ligands of Metabotropic Glutamate 7 (mGlu7) Receptor: 2008-present MedChemComm. Feb, 2019 | Pubmed ID: 30881607 Computationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 Receptor ACS Chemical Neuroscience. 03, 2019 | Pubmed ID: 30216043 Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization Journal of Medicinal Chemistry. 01, 2019 | Pubmed ID: 29494768 Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 Journal of Medicinal Chemistry. 08, 2017 | Pubmed ID: 28704052 Industrial Medicinal Chemistry Insights: Neuroscience Hit Generation at Janssen Drug Discovery Today. 10, 2017 | Pubmed ID: 28669605 Acylguanidine Beta Secretase 1 Inhibitors: A Combined Experimental and Free Energy Perturbation Study Journal of Chemical Theory and Computation. Mar, 2017 | Pubmed ID: 28103438 Application of Free Energy Perturbation for the Design of BACE1 Inhibitors Journal of Chemical Information and Modeling. 09, 2016 | Pubmed ID: 27500414 Towards Selective Phosphodiesterase 2A (PDE2A) Inhibitors: a Patent Review (2010 - Present) Expert Opinion on Therapeutic Patents. Aug, 2016 | Pubmed ID: 27321640 Molecular Mechanism of Positive Allosteric Modulation of the Metabotropic Glutamate Receptor 2 by JNJ-46281222 British Journal of Pharmacology. Feb, 2016 | Pubmed ID: 26589404 A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2015 | Pubmed ID: 26140617 N-Bridged 5,6-bicyclic Pyridines: Recent Applications in Central Nervous System Disorders European Journal of Medicinal Chemistry. Jun, 2015 | Pubmed ID: 25542766 QSAR Design of Triazolopyridine MGlu2 Receptor Positive Allosteric Modulators Journal of Molecular Graphics & Modelling. Sep, 2014 | Pubmed ID: 25086773 Dihydrothiazolopyridone Derivatives As a Novel Family of Positive Allosteric Modulators of the Metabotropic Glutamate 5 (mGlu5) Receptor Journal of Medicinal Chemistry. Sep, 2013 | Pubmed ID: 23947773 Pharmacological Characterization of JNJ-40068782, a New Potent, Selective, and Systemically Active Positive Allosteric Modulator of the MGlu2 Receptor and Its Radioligand [3H]JNJ-40068782 The Journal of Pharmacology and Experimental Therapeutics. Sep, 2013 | Pubmed ID: 23766542 MGluR2 Positive Allosteric Modulators: a Patent Review (2009 - Present) Expert Opinion on Therapeutic Patents. May, 2013 | Pubmed ID: 23452205 A Practical Entry to β-aryl-β-alkyl Amino Alcohols: Application to the Synthesis of a Potent BACE1 Inhibitor Organic & Biomolecular Chemistry. Sep, 2012 | Pubmed ID: 22810961 Imidazo[1,2-a]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor Journal of Medicinal Chemistry. Mar, 2012 | Pubmed ID: 22352782 New Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 (mGluR2): Identification and Synthesis of N-propyl-8-chloro-6-substituted Isoquinolones Bioorganic & Medicinal Chemistry Letters. Feb, 2011 | Pubmed ID: 21232953 Progress in the Developement of Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 Current Medicinal Chemistry. 2011 | Pubmed ID: 21110815 Easy Access to Aliphatic Sulfonamides using Sulfamoyl Chlorides Under Visible Light Activation Sandrine M. Hell1, Claudio F. Meyer1,2, Andrés A. Trabanco2, Véronique Gouverneur1 1Chemistry Research Laboratory, University of Oxford, 2Discovery Chemistry, Janssen Research and Development JoVE 61384 Chemistry
Easy Access to Aliphatic Sulfonamides using Sulfamoyl Chlorides Under Visible Light Activation Sandrine M. Hell1, Claudio F. Meyer1,2, Andrés A. Trabanco2, Véronique Gouverneur1 1Chemistry Research Laboratory, University of Oxford, 2Discovery Chemistry, Janssen Research and Development JoVE 61384 Chemistry