Sergei Zolotukhin

Publications

• Rational Design of AAV-rh74, AAV3B, and AAV8 with Limited Liver Targeting
  Viruses. Oct, 2023  |   Pubmed ID: 38005848
• Exploring the Comprehensive Kozak Sequence Landscape for AAV Production in Sf9 System
  Viruses. Sep, 2023  |   Pubmed ID: 37896760
• Intravitreal Injection of a Rationally Designed AAV Capsid Library in Non-human Primate Identifies Variants with Enhanced Retinal Transduction and Neutralizing Antibody Evasion
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2023  |   Pubmed ID: 37814449
• Characterization of a Bioengineered AAV3B Capsid Variant with Enhanced Hepatocyte Tropism and Immune Evasion
  Human Gene Therapy. Apr, 2023  |   Pubmed ID: 36950804
• Identification of Novel Retinal Pericyte-Targeting RAAV Vectors Through Directed Evolution
  Translational Vision Science & Technology. Aug, 2022  |   Pubmed ID: 36018583
• AAV Capsid Design: A Goldilocks Challenge
  Trends in Molecular Medicine. Mar, 2022  |   Pubmed ID: 35093287
• Scratching the Surface of RGD-directed AAV Capsid Engineering
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2021  |   Pubmed ID: 34699781
• Y1 Receptors Modulate Taste-related Behavioral Responsiveness in Male Mice to Prototypical Gustatory Stimuli
  Hormones and Behavior. Nov, 2021  |   Pubmed ID: 34509673
• A Comprehensive Study of a 29-capsid AAV Library in a Non-human Primate Central Nervous System
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2021  |   Pubmed ID: 34298128
• Mixture Interactions at Mammalian Olfactory Receptors Are Dependent on the Cellular Environment
  Scientific Reports. Apr, 2021  |   Pubmed ID: 33927269
• The CRTC1-MAML2 Fusion is the Major Oncogenic Driver in Mucoepidermoid Carcinoma
  JCI Insight. Apr, 2021  |   Pubmed ID: 33830080
• Applying Machine Learning to Predict Viral Assembly for Adeno-associated Virus Capsid Libraries
  Molecular Therapy. Methods & Clinical Development. Mar, 2021  |   Pubmed ID: 33511242
• Engineering and Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity
  Molecular Therapy. Methods & Clinical Development. Dec, 2020  |   Pubmed ID: 33145371
• Removal of Endotoxin from RAAV Samples Using a Simple Detergent-Based Protocol
  Molecular Therapy. Methods & Clinical Development. Dec, 2019  |   Pubmed ID: 31649960
• Taste Receptor Cells in Mice Express Receptors for the Hormone Adiponectin
  Chemical Senses. Jul, 2019  |   Pubmed ID: 31125082
• Achieving High-Yield Production of Functional AAV5 Gene Delivery Vectors Via Fedbatch in an Insect Cell-One Baculovirus System
  Molecular Therapy. Methods & Clinical Development. Jun, 2019  |   Pubmed ID: 30886878
• Helper-free Production of Laboratory Grade AAV and Purification by Iodixanol Density Gradient Centrifugation
  Molecular Therapy. Methods & Clinical Development. Sep, 2018  |   Pubmed ID: 30073177
• Direct Head-to-Head Evaluation of Recombinant Adeno-associated Viral Vectors Manufactured in Human Versus Insect Cells
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2017  |   Pubmed ID: 28890324
• An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8 T Cells
  Molecular Therapy. Methods & Clinical Development. Jun, 2017  |   Pubmed ID: 28480313
• Evaluation of Engineered AAV Capsids for Hepatic Factor IX Gene Transfer in Murine and Canine Models
  Journal of Translational Medicine. May, 2017  |   Pubmed ID: 28460646
• OneBac 2.0: Sf9 Cell Lines for Production of AAV1, AAV2, and AAV8 Vectors with Minimal Encapsidation of Foreign DNA
  Human Gene Therapy Methods. Feb, 2017  |   Pubmed ID: 28125901
• Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa
  PloS One. 2016  |   Pubmed ID: 27144303
• Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome
  PloS One. 2016  |   Pubmed ID: 26824232
• Snord116 is Critical in the Regulation of Food Intake and Body Weight
  Scientific Reports. Jan, 2016  |   Pubmed ID: 26726071
• Altering Tropism of RAAV by Directed Evolution
  Methods in Molecular Biology (Clifton, N.J.). 2016  |   Pubmed ID: 26611585
• High-accuracy Biodistribution Analysis of Adeno-associated Virus Variants by Double Barcode Sequencing
  Molecular Therapy. Methods & Clinical Development. 2015  |   Pubmed ID: 26793739
• Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?
  Human Gene Therapy. Dec, 2015  |   Pubmed ID: 26690810
• E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal--Tailored Acceleration of AAV Evolution
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2015  |   Pubmed ID: 26388463
• OneBac 2.0: Sf9 Cell Lines for Production of AAV5 Vectors with Enhanced Infectivity and Minimal Encapsidation of Foreign DNA
  Human Gene Therapy. Oct, 2015  |   Pubmed ID: 26134901
• A Simplified Purification Protocol for Recombinant Adeno-associated Virus Vectors
  Molecular Therapy. Methods & Clinical Development. 2014  |   Pubmed ID: 26015974
• Identification of Low-expressing Transcripts of the NPY Receptors' Family in the Murine Lingual Epithelia
  Methods in Molecular Biology (Clifton, N.J.). 2014  |   Pubmed ID: 25218388
• Vector Design Tour De Force: Integrating Combinatorial and Rational Approaches to Derive Novel Adeno-associated Virus Variants
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2014  |   Pubmed ID: 25048217
• OneBac: Platform for Scalable and High-titer Production of Adeno-associated Virus Serotype 1-12 Vectors for Gene Therapy
  Human Gene Therapy. Mar, 2014  |   Pubmed ID: 24299301
• Salivary Peptide Tyrosine-tyrosine 3-36 Modulates Ingestive Behavior Without Inducing Taste Aversion
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2013  |   Pubmed ID: 24259562
• Modulation of Taste Responsiveness by the Satiation Hormone Peptide YY
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2013  |   Pubmed ID: 24043261
• Structural Insights into Adeno-associated Virus Serotype 5
  Journal of Virology. Oct, 2013  |   Pubmed ID: 23926356
• Development of Novel Recombinant AAV Vectors and Strategies for the Potential Gene Therapy of Hemophilia
  Journal of Genetic Syndromes & Gene Therapy. Jan, 2012  |   Pubmed ID: 23264889
• Distribution of Y-receptors in Murine Lingual Epithelia
  PloS One. 2012  |   Pubmed ID: 23050020
• High-efficiency Transduction of Human Monocyte-derived Dendritic Cells by Capsid-modified Recombinant AAV2 Vectors
  Vaccine. Jun, 2012  |   Pubmed ID: 22497875
• Structural Insight into the Unique Properties of Adeno-associated Virus Serotype 9
  Journal of Virology. Jun, 2012  |   Pubmed ID: 22496238
• Neutralizing Antibodies Against AAV Serotypes 1, 2, 6, and 9 in Sera of Commonly Used Animal Models
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2012  |   Pubmed ID: 21915102
• Salivary PYY: a Putative Bypass to Satiety
  PloS One. 2011  |   Pubmed ID: 22028819
• High-efficiency Transduction and Correction of Murine Hemophilia B Using AAV2 Vectors Devoid of Multiple Surface-exposed Tyrosines
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010  |   Pubmed ID: 20736929
• An Animal Model of PDH Deficiency Using AAV8-siRNA Vector-mediated Knockdown of Pyruvate Dehydrogenase E1α
  Molecular Genetics and Metabolism. Oct-Nov, 2010  |   Pubmed ID: 20685142
• Production, Purification and Preliminary X-ray Crystallographic Studies of Adeno-associated Virus Serotype 9
  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Jul, 2009  |   Pubmed ID: 19574648
• An Inducible System for Highly Efficient Production of Recombinant Adeno-associated Virus (rAAV) Vectors in Insect Sf9 Cells
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009  |   Pubmed ID: 19279219
• High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2009  |   Pubmed ID: 19066593
• Tyrosine-phosphorylation of AAV2 Vectors and Its Consequences on Viral Intracellular Trafficking and Transgene Expression
  Virology. Nov, 2008  |   Pubmed ID: 18834608
• Next Generation of Adeno-associated Virus 2 Vectors: Point Mutations in Tyrosines Lead to High-efficiency Transduction at Lower Doses
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2008  |   Pubmed ID: 18511559
• Optimization of Recombinant Adeno-associated Viral Vectors for Human Beta-globin Gene Transfer and Transgene Expression
  Human Gene Therapy. Apr, 2008  |   Pubmed ID: 18399730
• Synergy Between Leptin Therapy and a Seemingly Negligible Amount of Voluntary Wheel Running Prevents Progression of Dietary Obesity in Leptin-resistant Rats
  Diabetes. Mar, 2008  |   Pubmed ID: 18086903
• Production, Purification and Preliminary X-ray Crystallographic Studies of Adeno-associated Virus Serotype 7
  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Dec, 2007  |   Pubmed ID: 18084098
• Structure of Adeno-associated Virus Serotype 8, a Gene Therapy Vector
  Journal of Virology. Nov, 2007  |   Pubmed ID: 17728238
• Ectopic Expression of Wnt10b Decreases Adiposity and Improves Glucose Homeostasis in Obese Rats
  American Journal of Physiology. Endocrinology and Metabolism. Sep, 2007  |   Pubmed ID: 17578883
• A Dual Role of EGFR Protein Tyrosine Kinase Signaling in Ubiquitination of AAV2 Capsids and Viral Second-strand DNA Synthesis
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2007  |   Pubmed ID: 17440440
• Production, Purification and Preliminary X-ray Crystallographic Studies of Adeno-associated Virus Serotype 1
  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Dec, 2006  |   Pubmed ID: 17142915
• Production, Purification, Crystallization and Preliminary X-ray Structural Studies of Adeno-associated Virus Serotype 5
  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Oct, 2005  |   Pubmed ID: 16511195
• Production, Purification, Crystallization and Preliminary X-ray Analysis of Adeno-associated Virus Serotype 8
  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Jun, 2005  |   Pubmed ID: 16511095
• Successful Production of Pseudotyped RAAV Vectors Using a Modified Baculovirus Expression System
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2005  |   Pubmed ID: 16213797
• Gene Therapy for Obesity
  Expert Opinion on Biological Therapy. Mar, 2005  |   Pubmed ID: 15833072
• Efficient Transduction of Vascular Endothelial Cells with Recombinant Adeno-associated Virus Serotype 1 and 5 Vectors
  Human Gene Therapy. Feb, 2005  |   Pubmed ID: 15761263
• Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism After Delivery to Different Regions of the Central Nervous System
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2004  |   Pubmed ID: 15294177
• Adeno-associated Virus Type 2 VP2 Capsid Protein is Nonessential and Can Tolerate Large Peptide Insertions at Its N Terminus
  Journal of Virology. Jun, 2004  |   Pubmed ID: 15163751
• Sustained Peripheral Expression of Transgene Adiponectin Offsets the Development of Diet-induced Obesity in Rats
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003  |   Pubmed ID: 14617771
• Identification of Amino Acid Residues in the Capsid Proteins of Adeno-associated Virus Type 2 That Contribute to Heparan Sulfate Proteoglycan Binding
  Journal of Virology. Jun, 2003  |   Pubmed ID: 12768018
• Production and Purification of Serotype 1, 2, and 5 Recombinant Adeno-associated Viral Vectors
  Methods (San Diego, Calif.). Oct, 2002  |   Pubmed ID: 12413414
• Streamlined Large-scale Production of Recombinant Adeno-associated Virus (rAAV) Vectors
  Methods in Enzymology. 2002  |   Pubmed ID: 11883083
• Transduction of Human and Mouse Pancreatic Islet Cells Using a Bicistronic Recombinant Adeno-associated Viral Vector
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2002  |   Pubmed ID: 11829522
• Efficient Photoreceptor-targeted Gene Expression in Vivo by Recombinant Adeno-associated Virus
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 1997  |   Pubmed ID: 9192666