Véronique Gouverneur Chemistry Research Laboratory University of Oxford Biography Publications Institution JoVE Articles Véronique Gouverneur has not added a biography. If you are Véronique Gouverneur and would like to personalize this page please email our Author Liaison for assistance. Publications Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery Journal of the American Chemical Society. May, 2020 | Pubmed ID: 32379965 [F]AZD2461, an Insight on Difference in PARP Binding Profiles for DNA Damage Response PET Imaging Molecular Imaging and Biology. Apr, 2020 | Pubmed ID: 32342268 Hydrosulfonylation of Alkenes with Sulfonyl Chlorides Under Visible Light Activation Angewandte Chemie (International Ed. in English). Jul, 2020 | Pubmed ID: 32286720 Manual and Automated Cu-mediated Radiosynthesis of the PARP Inhibitor [F]olaparib Nature Protocols. 04, 2020 | Pubmed ID: 32111986 F-Trifluoromethanesulfinate Enables Direct C-H F-Trifluoromethylation of Native Aromatic Residues in Peptides Journal of the American Chemical Society. 01, 2020 | Pubmed ID: 31913613 Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes Journal of the American Chemical Society. 01, 2020 | Pubmed ID: 31881153 Imaging of Translocator Protein Upregulation is Selective for Pro-inflammatory Polarized Astrocytes and Microglia Glia. 02, 2020 | Pubmed ID: 31479168 Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid Angewandte Chemie (International Ed. in English). 06, 2019 | Pubmed ID: 31020767 Synthesis of F-difluoromethylarenes Using Aryl Boronic Acids, Ethyl Bromofluoroacetate and [F]fluoride Chemical Science. Mar, 2019 | Pubmed ID: 30996907 Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines Journal of the American Chemical Society. 02, 2019 | Pubmed ID: 30689372 Synthesis and Reactivity of α-Cumyl Bromodifluoromethanesulfenate: Application to the Radiosynthesis of [ F]ArylSCF Angewandte Chemie (International Ed. in English). Feb, 2019 | Pubmed ID: 30575245 PET Imaging of PARP Expression Using F-Olaparib Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 04, 2019 | Pubmed ID: 30389822 Boron Reagents for Divergent Radiochemistry Chemical Society Reviews. Sep, 2018 | Pubmed ID: 30140795 Asymmetric Nucleophilic Fluorination Under Hydrogen Bonding Phase-transfer Catalysis Science (New York, N.Y.). 05, 2018 | Pubmed ID: 29748281 Controlled Single and Double Iodofluorination of Alkynes with DIH- and HF-Based Reagents Organic Letters. 03, 2018 | Pubmed ID: 29493242 Highly Diastereoselective Synthesis of Trifluoromethyl Indolines by Interceptive Benzylic Decarboxylative Cycloaddition of Nonvinyl, Trifluoromethyl Benzoxazinanones with Sulfur Ylides Under Palladium Catalysis Organic Letters. 03, 2018 | Pubmed ID: 29474077 Selective Radical Trifluoromethylation of Native Residues in Proteins Journal of the American Chemical Society. 02, 2018 | Pubmed ID: 29301396 F-Trifluoromethylation of Unmodified Peptides with 5-F-(Trifluoromethyl)dibenzothiophenium Trifluoromethanesulfonate Journal of the American Chemical Society. 02, 2018 | Pubmed ID: 29301394 Derisking the Cu-Mediated F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands Journal of the American Chemical Society. 06, 2017 | Pubmed ID: 28548849 The Dual Role of Thiourea in the Thiotrifluoromethylation of Alkenes Chemical Science. Feb, 2017 | Pubmed ID: 28451260 Synthesis and Reactivity of F-Labeled α,α-Difluoro-α-(aryloxy)acetic Acids Organic Letters. 02, 2017 | Pubmed ID: 28085289 Twisting the Ethano-Tröger's Base: the Bisamide Organic & Biomolecular Chemistry. Jan, 2017 | Pubmed ID: 27966723 Targeting Telomerase with Radiolabeled Inhibitors European Journal of Medicinal Chemistry. Jan, 2017 | Pubmed ID: 27657809 Asymmetric F-fluorination for Applications in Positron Emission Tomography Chemical Science. Mar, 2016 | Pubmed ID: 28808536 Bridging the Gaps in F PET Tracer Development Nature Chemistry. 12, 2016 | Pubmed ID: 27995923 Radiosynthesis of SPECT Tracers Via a Copper Mediated I Iodination of (hetero)aryl Boron Reagents Chemical Communications (Cambridge, England). Nov, 2016 | Pubmed ID: 27775106 Hydrogen-Bonded Homoleptic Fluoride-Diarylurea Complexes: Structure, Reactivity, and Coordinating Power Journal of the American Chemical Society. Oct, 2016 | Pubmed ID: 27608274 Ultrafast Click Chemistry with Fluorosydnones Angewandte Chemie (International Ed. in English). 09, 2016 | Pubmed ID: 27560312 Enhanced Copper-mediated (18)F-fluorination of Aryl Boronic Esters Provides Eight Radiotracers for PET Applications Chemical Communications (Cambridge, England). Jun, 2016 | Pubmed ID: 27241832 Copper-Catalyzed Insertion into Heteroatom-Hydrogen Bonds with Trifluorodiazoalkanes Angewandte Chemie (International Ed. in English). Mar, 2016 | Pubmed ID: 26880039 (18)F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography Chemical Reviews. Jan, 2016 | Pubmed ID: 26751274 Synthesis and Characterization of a Novel N-F Reagent Derived from the Ethano-Tröger's Base: (1)J(FN) Coupling Constants As a Signature for the N-F Bond Chemical Communications (Cambridge, England). Jan, 2016 | Pubmed ID: 26658721 Coordination Diversity in Hydrogen-bonded Homoleptic Fluoride-alcohol Complexes Modulates Reactivity Chemical Science. Sep, 2015 | Pubmed ID: 29449931 Synthesis of F-Arenes from Spirocyclic Iodonium(III) Ylides Via Continuous-Flow Microfluidics Journal of Fluorine Chemistry. Oct, 2015 | Pubmed ID: 27512233 Organomediated Enantioselective (18)F Fluorination for PET Applications Angewandte Chemie (International Ed. in English). Nov, 2015 | Pubmed ID: 26360631 (18)F-Labeling of Aryl-SCF3, -OCF3 and -OCHF2 with [(18)F]Fluoride Angewandte Chemie (International Ed. in English). Aug, 2015 | Pubmed ID: 26140357 Cross-Coupling of [2-Aryl-1,1,2,2-tetrafluoroethyl](trimethyl)silanes with Aryl Halides Organic Letters. Jul, 2015 | Pubmed ID: 26126930 Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film Using a Fluorocarbon Gas Angewandte Chemie (International Ed. in English). Jul, 2015 | Pubmed ID: 26068966 A Dual Radiolabelling Approach for Tracking Metal Complexes: Investigating the Speciation of Copper Bis(thiosemicarbazonates) in Vitro and in Vivo Metallomics : Integrated Biometal Science. May, 2015 | Pubmed ID: 25768310 Anti-CD20 Inhibits T Cell-mediated Pathology and Microgliosis in the Rat Brain Annals of Clinical and Translational Neurology. Sep, 2014 | Pubmed ID: 25493280 Asymmetric Fluorocyclizations of Alkenes Accounts of Chemical Research. Dec, 2014 | Pubmed ID: 25379791 Diversity-oriented Approach to CF3CHF-, CF3CFBr-, CF3CF2-, (CF3)2CH-, and CF3(SCF3)CH-substituted Arenes from 1-(diazo-2,2,2-trifluoroethyl)arenes Organic Letters. Nov, 2014 | Pubmed ID: 25379614 A General Copper-mediated Nucleophilic 18F fluorination of Arenes Angewandte Chemie (International Ed. in English). Jul, 2014 | Pubmed ID: 24916101 Cis-Specific Hydrofluorination of Alkenylarenes Under Palladium Catalysis Through an Ionic Pathway Angewandte Chemie (International Ed. in English). Apr, 2014 | Pubmed ID: 24644083 Glial Activation in the Early Stages of Brain Metastasis: TSPO As a Diagnostic Biomarker Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Feb, 2014 | Pubmed ID: 24434290 A Comparison of the Behavior of (64)Cu-acetate and (64)Cu-ATSM in Vitro and in Vivo Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2014 | Pubmed ID: 24337603 Enhanced Aqueous Suzuki-Miyaura Coupling Allows Site-specific Polypeptide 18F-labeling Journal of the American Chemical Society. Sep, 2013 | Pubmed ID: 23991754 Intramolecular OH···FC Hydrogen Bonding in Fluorinated Carbohydrates: CHF is a Better Hydrogen Bond Acceptor Than CF2 Angewandte Chemie (International Ed. in English). Sep, 2013 | Pubmed ID: 23960019 Asymmetric Electrophilic Fluorocyclization with Carbon Nucleophiles Angewandte Chemie (International Ed. in English). Sep, 2013 | Pubmed ID: 23873744 Catalytic Decarboxylative Fluorination for the Synthesis of Tri- and Difluoromethyl Arenes Organic Letters. Jun, 2013 | Pubmed ID: 23687958 Trifluoromethylation of Allylsilanes Under Photoredox Catalysis Organic Letters. Mar, 2013 | Pubmed ID: 23465076 Catalytic Hydrotrifluoromethylation of Unactivated Alkenes Journal of the American Chemical Society. Feb, 2013 | Pubmed ID: 23373772 [18F]fluorination of an Arylboronic Ester Using [18F]selectfluor Bis(triflate): Application to 6-[18F]fluoro-L-DOPA Chemical Communications (Cambridge, England). Feb, 2013 | Pubmed ID: 23321570 18F Labeling of Arenes Angewandte Chemie (International Ed. in English). Nov, 2012 | Pubmed ID: 23086547 Conformational Analysis of Fluorinated Pyrrolidines Using 19F-1H Scalar Couplings and Heteronuclear NOEs Chemistry (Weinheim an Der Bergstrasse, Germany). Oct, 2012 | Pubmed ID: 22991298 Synthesis of 3-fluoropyrrolidines and 4-fluoropyrrolidin-2-ones from Allylic Fluorides Chemistry (Weinheim an Der Bergstrasse, Germany). Oct, 2012 | Pubmed ID: 22991281 Trifluoromethylation of Allylsilanes Under Copper Catalysis Chemistry (Weinheim an Der Bergstrasse, Germany). Jul, 2012 | Pubmed ID: 22692972 Metal-free Oxidative Fluorination of Phenols with [18F]fluoride Angewandte Chemie (International Ed. in English). Jul, 2012 | Pubmed ID: 22639017 Palladium-catalyzed Substitution and Cross-coupling of Benzylic Fluorides Organic Letters. Jun, 2012 | Pubmed ID: 22594918 Transition Metal Catalysis and Nucleophilic Fluorination Chemical Communications (Cambridge, England). Mar, 2012 | Pubmed ID: 22334339 A Fluorous and Click Approach for Screening Potential PET Probes: Evaluation of Potential Hypoxia Biomarkers Bioorganic & Medicinal Chemistry. Jan, 2012 | Pubmed ID: 22130421 Hypoxia Imaging Using PET and SPECT: the Effects of Anesthetic and Carrier Gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO Tumor Hypoxia Accumulation PloS One. 2011 | Pubmed ID: 22102855 Organocatalyzed Enantioselective Fluorocyclizations Angewandte Chemie (International Ed. in English). Aug, 2011 | Pubmed ID: 21751319 Au(I) /Au(III) Catalysis: an Alternative Approach for C-C Oxidative Coupling Chemistry (Weinheim an Der Bergstrasse, Germany). Jul, 2011 | Pubmed ID: 21678513 Palladium-catalyzed Allylic Fluorination Angewandte Chemie (International Ed. in English). Mar, 2011 | Pubmed ID: 21370349 The Chemoselective One-step Alkylation and Isolation of Thiophosphorylated Cdk2 Substrates in the Presence of Native Cysteine Chembiochem : a European Journal of Chemical Biology. Mar, 2011 | Pubmed ID: 21305681 The Traceless Staudinger Ligation for Indirect 18F-radiolabelling Organic & Biomolecular Chemistry. Jan, 2011 | Pubmed ID: 21103523 Gold-catalyzed Cascade Cyclization-oxidative Alkynylation of Allenoates Organic Letters. Nov, 2010 | Pubmed ID: 20936849 Catalytic Enantioselective Synthesis of P-stereogenic Compounds Chemical Communications (Cambridge, England). Oct, 2010 | Pubmed ID: 20835471 Radiosynthesis and Evaluation of [18F]Selectfluor Bis(triflate) Angewandte Chemie (International Ed. in English). Sep, 2010 | Pubmed ID: 20715033 Pre-clinical Evaluation of a 3-nitro-1,2,4-triazole Analogue of [18F]FMISO As Hypoxia-selective Tracer for PET Nuclear Medicine and Biology. Jul, 2010 | Pubmed ID: 20610161 Orthogonal 18F and 64Cu Labelling of Functionalised Bis(thiosemicarbazonato) Complexes Chemical Communications (Cambridge, England). Jun, 2010 | Pubmed ID: 20407674 Bis(thiosemicarbazones) As Bifunctional Chelators for the Room Temperature 64-copper Labeling of Peptides Dalton Transactions (Cambridge, England : 2003). Apr, 2010 | Pubmed ID: 20354615 Gold-catalyzed Intramolecular Oxidative Cross-coupling of Nonactivated Arenes Chemistry (Weinheim an Der Bergstrasse, Germany). Apr, 2010 | Pubmed ID: 20340120 Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside Analogues Organic & Biomolecular Chemistry. Mar, 2010 | Pubmed ID: 20204220 Diastereoselective Synthesis of P-stereogenic Heterocycles Via Enyne Ring-closing Metathesis Organic Letters. Mar, 2010 | Pubmed ID: 20184294 Developments in Fluorocyclization Methodologies Future Medicinal Chemistry. Aug, 2009 | Pubmed ID: 21426084 Transition-metal-mediated Reactions for C(sp2)-F Bond Construction: the State of Play Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19827068 Chemistry. A New Departure in Fluorination Chemistry Science (New York, N.Y.). Sep, 2009 | Pubmed ID: 19779178 Electrophilic Fluorocyclization of Allyl Silanes Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19697388 Synthesis and Reactivity of Novel Gamma-phosphate Modified ATP Analogues Bioorganic & Medicinal Chemistry Letters. Jul, 2009 | Pubmed ID: 19410453 Diels-Alder Exo Selectivity in Terminal-substituted Dienes and Dienophiles: Experimental Discoveries and Computational Explanations Journal of the American Chemical Society. Feb, 2009 | Pubmed ID: 19154113 Enantioselective Synthesis of P-stereogenic Phosphinates and Phosphine Oxides by Molybdenum-catalyzed Asymmetric Ring-closing Metathesis Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19101976 A Two-directional Approach to Enantiopure 1,4-difluoro-cyclohexenes: Synthesis of Difluorinated Cyclitol Analogues Organic Letters. Oct, 2008 | Pubmed ID: 18763795 Gold(I)-catalyzed Alkoxyhalogenation of Beta-hydroxy-alpha,alpha-difluoroynones Angewandte Chemie (International Ed. in English). 2008 | Pubmed ID: 18683842 Fluorous Synthesis of Allylic Fluorides: C-F Bond Formation As the Detagging Process Chemical Communications (Cambridge, England). Aug, 2008 | Pubmed ID: 18665278 The Chemistry of Propargylic and Allylic Fluorides Chemical Reviews. Jun, 2008 | Pubmed ID: 18543877 Stereospecific Anti SE2' Fluorination of Allenylsilanes: Synthesis of Enantioenriched Propargylic Fluorides Organic & Biomolecular Chemistry. May, 2008 | Pubmed ID: 18452005 Fluorine-directed Diastereoselective Iodocyclizations Angewandte Chemie (International Ed. in English). 2008 | Pubmed ID: 18022878 Single and Double Stereoselective Fluorination of (E)-allylsilanes Beilstein Journal of Organic Chemistry. Oct, 2007 | Pubmed ID: 17961218 Synthesis and Reactivity of [18F]-N-fluorobenzenesulfonimide Chemical Communications (Cambridge, England). Jun, 2007 | Pubmed ID: 17844736 A Concise Synthesis of Enantioenriched Fluorinated Carbocycles Angewandte Chemie (International Ed. in English). 2007 | Pubmed ID: 17549786 Enantioselective Organocatalytic Aldol Reaction of Ynones and Its Synthetic Applications Organic Letters. Nov, 2006 | Pubmed ID: 17078732 Sequential Desymmetrization-fluorination: Enantioselective Synthesis of Fluorinated Cyclitols Chemistry (Weinheim an Der Bergstrasse, Germany). Dec, 2006 | Pubmed ID: 17066392 Pd(II)-catalyzed Cascade Wacker-Heck Reaction: Chemoselective Coupling of Two Electron-deficient Reactants The Journal of Organic Chemistry. Oct, 2006 | Pubmed ID: 17064010 Synthesis of Propargylic Fluorides from Allenylsilanes Chemical Communications (Cambridge, England). Oct, 2006 | Pubmed ID: 17024266 Intramolecular Hetero-Michael Addition of Beta-hydroxyenones for the Preparation of Highly Substituted Tetrahydropyranones Chemistry (Weinheim an Der Bergstrasse, Germany). Sep, 2006 | Pubmed ID: 16819725 Enantioselective Synthesis of a Key "A-ring" Intermediate for the Preparation of 1alpha-fluoro Vitamin D3 Analogues The Journal of Organic Chemistry. Jul, 2006 | Pubmed ID: 16808527 Catalytic Asymmetric Fluorinations Organic & Biomolecular Chemistry. Jun, 2006 | Pubmed ID: 16729117 Electrophilic Fluorination of Organosilanes Organic & Biomolecular Chemistry. Jan, 2006 | Pubmed ID: 16357989 Diastereoselective Ring-closing Metathesis: Synthesis of P-stereogenic Phosphinates from Prochiral Phosphinic Acid Derivatives The Journal of Organic Chemistry. Dec, 2005 | Pubmed ID: 16356003 Palladium-catalyzed Oxidative Cyclizations: Synthesis of Dihydropyranones and Furanones The Journal of Organic Chemistry. Oct, 2005 | Pubmed ID: 16209595 Synthesis of Novel Enantiopure Fluorinated Building Blocks from Acyclic Chiral Allylsilanes Organic Letters. Sep, 2005 | Pubmed ID: 16178567 Biocatalytic Approaches to Hetero-Diels-Alder Adducts of Carbonyl Compounds Chemistry (Weinheim an Der Bergstrasse, Germany). Oct, 2005 | Pubmed ID: 16003810 Electrophilic Fluorodesilylation of Allenylmethylsilanes: a Novel Entry to 2-fluoro-1,3-dienes Organic Letters. Mar, 2005 | Pubmed ID: 15787483 A Catalytic Asymmetric Bioorganic Route to Enantioenriched Tetrahydro- and Dihydropyranones Journal of the American Chemical Society. Feb, 2005 | Pubmed ID: 15686381 Stereoselective Synthesis of Internal Allylic Fluorides Organic & Biomolecular Chemistry. Apr, 2004 | Pubmed ID: 15064784 Oxidative Cyclization of Beta-hydroxyenones with Palladium(II): a Novel Entry to 2,3-dihydro-4H-pyran-4-ones Organic Letters. Jan, 2004 | Pubmed ID: 14703358 Sequential Cross-metathesis/electrophilic Fluorodesilylation: a Novel Entry to Functionalized Allylic Fluorides Organic Letters. Dec, 2003 | Pubmed ID: 14653700 Synthesis of Unprotected and Borane-protected Cyclic Phosphines Using Ru- and Mo- Based Olefin Metathesis Catalysts Organic & Biomolecular Chemistry. Nov, 2003 | Pubmed ID: 14649914 Regio- and Enantioselective Synthesis of Allylic Fluorides by Electrophilic Fluorodesilylation of Allyl Silanes Angewandte Chemie (International Ed. in English). Jul, 2003 | Pubmed ID: 12876747 Unprecedented Regiocontrol Using an Aldolase I Antibody Angewandte Chemie (International Ed. in English). Mar, 2002 | Pubmed ID: 12491296 Synthetic Applications of Electrophilic Fluorodesilylation Chemistry (Weinheim an Der Bergstrasse, Germany). Feb, 2002 | Pubmed ID: 11857690 Easy Access to Aliphatic Sulfonamides using Sulfamoyl Chlorides Under Visible Light Activation Sandrine M. Hell1, Claudio F. Meyer1,2, Andrés A. Trabanco2, Véronique Gouverneur1 1Chemistry Research Laboratory, University of Oxford, 2Discovery Chemistry, Janssen Research and Development JoVE 61384 Chemistry
Easy Access to Aliphatic Sulfonamides using Sulfamoyl Chlorides Under Visible Light Activation Sandrine M. Hell1, Claudio F. Meyer1,2, Andrés A. Trabanco2, Véronique Gouverneur1 1Chemistry Research Laboratory, University of Oxford, 2Discovery Chemistry, Janssen Research and Development JoVE 61384 Chemistry