North China University of Science and Technology 1 article published in JoVE Medicine Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica Fuyu Jin1, Yaqian Li1, Tian Li1, Xinyu Yang1, Wenchen Cai1, Shifeng Li1, Xuemin Gao1, Fang Yang1, Hong Xu1, Heliang Liu1 1Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology This study describes a technique to establish a silicosis rat model with the inhalation of silica through the whole body in an inhalation chamber. The rats with silicosis could closely mimic the pathological process of human silicosis in an easy, cost-effective manner with good repeatability.