South Ural State University 1 article published in JoVE Chemistry Study of Short Peptide Adsorption on Solution Dispersed Inorganic Nanoparticles Using Depletion Method Elena Korina1, Sergei Naifert1, Roman Morozov1, Vladimir Potemkin1,2, Oleg Bol'shakov1 1Nanotechnology Education and Research Center, South Ural State University, 2Laboratory of Computational Modelling of Drugs, South Ural State University The first step in comprehending biomolecule-inorganic solid phase interaction is revealing fundamental physicochemical constants that may be evaluated by establishing adsorption isotherms. Adsorption from the liquid phase is restricted by kinetics, surface capacity, pH, and competitive adsorption, which all should be cautiously considered before setting an adsorption experiment.