Kepler-Gymnasium Freiburg 1 article published in JoVE Immunology and Infection Granulocyte-dependent Autoantibody-induced Skin Blistering Kinga Csorba1, Sebastian Sitaru2, Cassian Sitaru1,3 1Department of Dermatology, University of Freiburg, 2Kepler High School Freiburg, 3Centre for Biological Signalling Studies (BIOSS), University of Freiburg In the animal model described in our present work, purified IgG antibodies against a stretch of 200 amino acids (aa 757-967) of collagen VII are injected repeatedly into mice reproducing the blistering phenotype as well as the histo- and immunopathological features characteristic to human epidermolysis bullosa acquisita (EBA)1.