Nantes Universite 1 article published in JoVE Medicine Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice Samuel Frey1,2, Audrey Ayer1, Thibaud Sotin1, Victoria Lorant1, Bertrand Cariou1, Claire Blanchard*1,2, Cédric Le May*1 1CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes Université, 2Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Hôtel Dieu, CHU Nantes Single-anastomosis duodeno-ileal bypass (SADI-S) is an emerging bariatric procedure with important metabolic effects. In this article, we present a reliable and reproducible model of SADI-S in mice.