University of Illinois College of Medicine 1 article published in JoVE Bioengineering Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training Megan S. Mattus1, Tate B. Ralph1, Sister M. Pieta Keller1, Alexa L. Waltz2, Matthew T. Bramlet2 1Jump Simulation, OSF HealthCare, 2Advanced Imaging and Modeling Lab, OSF HealthCare Jump Trading Simulation & Education Center, University of Illinois College of Medicine Patient-specific models improve surgeon and fellow confidence when developing or learning surgical plans. Three-dimensional (3D) printers generate adequate detail for surgical preparation, but fail to replicate tissue haptic fidelity. A protocol is presented detailing the creation of patient-specific, silicone cardiac models, combining 3D printing precision with simulated silicone tissue.