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Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery
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Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

Article DOI: 10.3791/64314-v • 06:29 min • October 20th, 2023
October 20th, 2023 •
1,2, 1, 1, 3
1Animal Surgery and Resources Core, National Heart, Lung, and Blood Institute, National Institutes of Health, 2College of Veterinary Medicine, Mississippi State University, 3Division of Veterinary Resources, Office of Research Services, National Institutes of Health

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Summary
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We describe how to generate a widely used surgical model of intestinal ischemia-reperfusion injury (IRI) in rodents. The procedure involves occlusion of the superior mesenteric artery followed by the restoration of blood flow. This model is useful for studies investigating occlusive causes of intestinal IRI in both veterinary and human medicine.

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Intestinal Ischemia-reperfusion Injury Rodent Model Superior Mesenteric Artery Occlusion Gastric Dilatation Volvulus Mesenteric Torsion Colic Free Radical Formation Oxygen Reintroduction Poor Prognosis In Vivo Model Isoflurane Anesthesia Reproducible Injury Histopathology Small Intestines Colon Liver Kidneys
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